{"id":3691,"date":"2022-08-26T10:27:00","date_gmt":"2022-08-26T08:27:00","guid":{"rendered":"https:\/\/www.labex-lipstic.fr\/?p=3691"},"modified":"2022-08-26T14:54:59","modified_gmt":"2022-08-26T12:54:59","slug":"the-lnc-umr1231-ctm-is-the-laureate-of-the-anr-labcom-project-call-aap-anr-2022","status":"publish","type":"post","link":"https:\/\/www.labex-lipstic.fr\/en\/the-lnc-umr1231-ctm-is-the-laureate-of-the-anr-labcom-project-call-aap-anr-2022\/","title":{"rendered":"THE LNC UMR1231 (CTM) IS THE LAUREATE OF THE ANR LABCOM PROJECT CALL AAP ANR 2022"},"content":{"rendered":"
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Le laboratoire Commun d’Ing\u00e9nierie des Anticorps Monoclonaux Innovants \u00e0 vis\u00e9e Th\u00e9rapeutique, IAM-IT, est l’un des 7 projets s\u00e9lectionn\u00e9s dans le cadre de la premi\u00e8re vague de l\u2019\u00e9dition 2022 de l\u2019appel \u00e0 projets LabCom,\u00a0annonce ANR\u00a0<\/a>du 25\/07\/2022.<\/p>\n

\u2022 IAM-IT a pour objectif de d\u00e9velopper de nouvelles approches m\u00e9dicamenteuses et des outils de diagnostic ou de recherche, bas\u00e9s sur des anticorps monoclonaux g\u00e9n\u00e9r\u00e9s par une m\u00e9thode innovante d\u2019immunisation, mise en place conjointement par le Laboratoire acad\u00e9mique\u00a0INSERM UMR1231<\/a>\u00a0de l\u2019universit\u00e9\u00a0Bourgogne Franche-Comt\u00e9 (UBFC)<\/a>\u00a0et la soci\u00e9t\u00e9\u00a0COVALAB<\/a>\u00a0(1).<\/p>\n

\u2022 L\u2019approche technologique au c\u0153ur du projet offre la possibilit\u00e9 de d\u00e9velopper 1) des anticorps reconnaissant des prot\u00e9ines d\u2019int\u00e9r\u00eat dans leur conformation naturelle, dite \u00e9galement tri-dimensionnelle, et seulement sous cette forme, 2) des tests compagnons, permettant d\u2019une part de pr\u00e9ciser finement et rapidement, les interactions de l\u2019anticorps avec sa cible et de proposer 3) des outils de diagnostics qui pourraient s\u2019appliquer par exemple au suivi d\u2019\u00e9chantillons biologiques de patients, \u00e0 la s\u00e9lection d\u2019anticorps th\u00e9rapeutiques r\u00e9sistant aux mutations de la prot\u00e9ine cible ou de cartographier les \u00e9pitopes reconnus par des anticorps th\u00e9rapeutiques. Dans le contexte actuel de pand\u00e9mie, cette technologie permettrait de s\u00e9lectionner des anticorps th\u00e9rapeutiques r\u00e9sistants aux mutants SARS-COV2, par exemple.<\/p>\n

L\u2019\u00e9mergence des approches th\u00e9rapeutiques d\u2019immunoth\u00e9rapie ouvrent des perspectives d\u2019innovation importantes, qui environn\u00e9es du CTM permettraient de p\u00e9renniser le laboratoire commun au profit du CTM et de COVALAB et ce bien au-del\u00e0 du microenvironnement r\u00e9gional d\u2019UBFC. Le programme de recherche conjoint s\u2019appuiera sur les comp\u00e9tences reconnues du CTM (centre de recherche translationnel de m\u00e9decine mol\u00e9culaire) en recherche translationnelle et en d\u00e9veloppement technologique, et de COVALAB pour son expertise dans l\u2019ing\u00e9nierie des anticorps et de leur valorisation.<\/p>\n

Le projet IAM-IT est port\u00e9 par le\u00a0Dr Olivier Micheau (UMR1231, CTM)<\/strong>\u00a0en collaboration avec l\u2019entreprise COVALAB dirig\u00e9e par le\u00a0Dr Said El Alaoui<\/strong>. Dot\u00e9 de 363 k\u20ac sur 54 mois, le projet fera l\u2019objet d\u2019une gouvernance commune par les porteurs de projet qui prendront conseil aupr\u00e8s d\u2019un comit\u00e9 strat\u00e9gique externe compos\u00e9 de membres \u00e9minents (personnalit\u00e9s scientifiques et des industriels) pour d\u00e9finir la feuille de route et p\u00e9renniser la strat\u00e9gie du laboratoire commun. Le projet b\u00e9n\u00e9ficiera de l\u2019accompagnement d\u2019INSERM transfert pour la valorisation. Son objectif \u00e0 plus ou moins long terme est de pouvoir valoriser les avanc\u00e9es th\u00e9rapeutiques \u00e9mergentes du CTM, contribuer aux innovations th\u00e9rapeutiques \u00e0 venir et au rayonnement de la France en sant\u00e9 publique.<\/p>\n

(1) Dubuisson et al.\u00a0Cell Death & Disease\u00a0<\/a>2019.<\/p>\n<\/div>\n<\/div>\n

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Renseignements – omicheau@u-bourgogne.fr Tel: 03 80 39 34 68<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Le laboratoire Commun d’Ing\u00e9nierie des Anticorps Monoclonaux Innovants \u00e0 vis\u00e9e Th\u00e9rapeutique, IAM-IT, est l’un des 7 projets s\u00e9lectionn\u00e9s dans le cadre de la premi\u00e8re vague de l\u2019\u00e9dition 2022 de l\u2019appel \u00e0 projets LabCom,\u00a0annonce ANR\u00a0du 25\/07\/2022. \u2022 IAM-IT a pour objectif de d\u00e9velopper de nouvelles approches m\u00e9dicamenteuses et des outils de diagnostic ou de recherche, bas\u00e9s […]<\/p>\n","protected":false},"author":3,"featured_media":3715,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"acf":[],"yoast_head":"\nTHE LNC UMR1231 (CTM) IS THE LAUREATE OF THE ANR LABCOM PROJECT CALL AAP ANR 2022 - Labex Lipstic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.labex-lipstic.fr\/en\/the-lnc-umr1231-ctm-is-the-laureate-of-the-anr-labcom-project-call-aap-anr-2022\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"THE LNC UMR1231 (CTM) IS THE LAUREATE OF THE ANR LABCOM PROJECT CALL AAP ANR 2022 - 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